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Clinical constipation is defined as fewer than 3 bowel movements per week, often accompanied by hard stools requiring excessive straining and incomplete evacuation feeling

The implications of OS in hepatic diseases in dogs have been studied through the quantification of oxidants and antioxidants in various samples, such as blood, urine, and liver tissue, using a range of methods [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104]

Diabetes Obes Metab 14(Suppl 2):4149 Gabery S, Salinas CG, Paulsen SJ et al (2020) Semaglutide lowers body weight in rodents via distributed neural pathways

Cent Nerv Syst Agents Med Chem 19(3):154170

Consequently, these properties are now widely recognized as a primary impediment to the clinical translation of PROTACs, particularly restricting their therapeutic potential in oncology and neurodegenerative diseases [75]