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However, direct comparisons require caution because: Trial lengths differed Dosing protocols differed Patient populations differed Long-term orforglipron data is still developing A 5% to 10% reduction in body weight can still produce clinically meaningful improvements in blood pressure, insulin sensitivity, mobility, and metabolic health

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KosiborodMNAbildstrmSZBorlaugBAButlerJRasmussenSDaviesMet alSemaglutide in patients with heart failure with preserved ejection fraction and obesity