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10.3389/fphar.2021.748867 101 LinX.XiaoZ.ChenT.LiangS

This is a series of Phase 3 trials studying retatrutide across multiple conditions: TRIUMPH-1 : Obesity (basket trial with nested OSA and OA protocols) TRIUMPH-2 : Obesity in type 2 diabetes population (with nested OSA) TRIUMPH-3 : Weight management in cardiovascular disease population TRIUMPH-4 : Obesity with knee osteoarthritis (completed results December 2025) Additional trials covering MASLD (metabolic dysfunction-associated steatotic liver disease), cardiovascular/renal outcomes, chronic low back pain, and weight maintenance TRANSCEND program: Dedicated type 2 diabetes trials (separate from TRIUMPH) TRIUMPH-4 was the first Phase 3 trial to report results, announced in December 2025

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