DNA damage and oxidative stress generated by radiation and/or chemotherapy activate key inflammatory pathways, ultimately resulting in the destruction of the epithelial barrier, leading to microbial colonization, and ulceration
[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Paratore S., Ciotti M.T., Basille M., Vaudry D., Gentile A., Parenti R., Calissano P., Cavallaro S
doi:10.1007/s10162-020-00781-0
This early response involves proximal small-intestinal L-cells alongside neural and hormonal signals, including vagal nerve activation and the release of gastric hormones
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