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The most reliable indicator of degradation that does not show on visual inspection is reduced effectiveness
Roper (resilience idea): A resilient cashflow compounder in the software space with inflecting growth
The main advantage of GLP-1s compared to previous treatments is that the rate of response is very high across the board. Azagury and Ali both noted that side effects are not necessarily dependent on someones health conditions and that they can vary greatly from person to person
Planning for indefinite treatment from the beginning creates realistic expectations
In Vitro GLP-1R agonist 2 (100 nM, 1,000 nM) activates GLP-1 receptor-mediated cAMP production, with an EC 50 of 101 nM, but exhibits a self-limiting effect at high concentrations [2]
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