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Nutrients 12(6):1790

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In brief, serum proteins were alkylated with iodoacetamide, digested with trypsin and spiked with heavy isotope-labelled synthetic peptide analogues (PEPotec, Thermo Fisher Scientific, USA)

Semaglutide has received FDA approval for distinct clinical indications based on formulation and dosing regimen, reflecting its versatility as a GLP-1 receptor agonist