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Research in this pediatric age group remains limited, although one randomized study found that teens using semaglutide lost about 17% of their starting weight after one year, compared to 3% to 4% with lifestyle modification alone

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Importantly, these efficacy results were seen with very low rates of clinically significant hypoglycemia and a safety and tolerability profile consistent with the GLP-1 receptor agonist class. Study design For the phase 3 trial, Frias and colleagues analyzed data from 1,879 adults with type 2 diabetes inadequately controlled with metformin therapy of at least 1,500 mg daily (mean age, 57 years

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