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SEP-631 substantially inhibited icatibant 10 g/mL-induced wheals at 10 mg QD, the lowest dose of SEP-631 that was evaluated in the study (Figure 8.A)

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In wt cells, the OxD values differed only slightly between the three compartments and deletion of GLR1 resulted in increased OxD values at steady state in all three compartments (Figure 3B)

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