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Additionally, the delayed gastric emptying induced by GLP-1 agonists could theoretically worsen symptoms in patients with stricturing Crohn's disease or those at risk for bowel obstruction

Certain NSAIDs (e.g., selective COX-2 inhibitors) have been linked to an increased risk of cardiovascular events, in particular heart attack

Inflammation can be a mediator of insulin resistance and beta-cell damage by high glucose, fatty acids, or adipokines released from adipose tissues [3739]

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