doi:10.1007/s00394-014-0706-z Shimizu H, Kiyohara Y, Kato I, et al
Second, targeting eryptosis pathways offers new therapeutic opportunities: strategies to mitigate eryptosis could include optimizing clearance of eryptosis-inducing uremic toxins via advanced dialysis modalities (e.g., hemodialysis combined with hemadsorption [HA + HD] for protein-bound uremic toxins) or novel pharmacotherapies, such as inhibitors of Organic Anion Transporter 2 (OAT2) to block indoxyl sulfate uptake by erythrocytes, antioxidants (e.g., N-acetyl-L-cysteine, vitamin E) to counteract oxidative stress-mediated eryptosis, or modulators of Ca 2+ signaling (e.g., NO donors) to stabilize erythrocyte membrane asymmetry
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Freezing a mixed multi-use vial can create solution changes and freeze-thaw stress that are not worth accepting unless a protocol specifically requires aliquoted frozen storage
How the WeightCare program works The WeightCare process follows four steps