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doi: 10.2337/db20-0579 41 ShihSCClaffeyKP

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This dual affinity creates a unique pharmacological effect within the family: cardioprotection demonstrated in myocardial ischemia-reperfusion models with a 2540% reduction in infarct size, an effect preserved in GHS-R1a knockout animals but abolished in CD36 knockout animals (formal mechanistic evidence of the CD36-independent pathway)