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The plant is cultivated in many countries, including India, China, Nepal, the United States, Bangladesh, Jamaica, Nigeria, and Taiwan, whereby India is the worlds largest producer (Kumar et al., 2011)

Specifically, a fine balance of intracellular spermidine and ROS levels likely determine proliferation, autophagy, differentiation to metacyclic trypomastigote form, as well as antioxidant capacity while the parasite gets ready to enter the mammalian host

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Together, these peptides are referenced in preclinical literature for their relationship to receptor-mediated signaling, feedback mechanisms, and metabolic pathway modulation under controlled experimental conditions