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Degradation of glucagon-like peptide-1 by human plasma in vitro yields an n-terminally truncated peptide that is a major endogenous metabolite in vivo

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Use your genes to find your susceptibility: GLP-1s make it easy not to eat, which can end up causing nutritional deficiencies if you arent eating enough nutrient-dense whole foods

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The strategy was, therefore, to identify GLP-1 mimetic drugs with a molecular structure close enough to native GLP-1 to stimulate the GLP-1 receptor, but with alterations that enabled prolonged activity by, in particular, possessing resistance to breakdown by DPP-4 (Meier, 2012)

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