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PLoS One 10:e0138317 Shi Q, Liu S, Fonseca VA, Thethi TK, Shi L (2019) Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus

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1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG

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