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In COVID-19 patients, FeRD could trigger several clinical manifestations including (i) decrease functional hemoglobin (Hb), (ii) increase cellular iron overload, (iii) release free toxic heme into the circulation, (iv) manifest hypoxemia and systemic hypoxia, (v) reduce nitric oxide (NO) synthesis, (vi) activate coagulation pathway(s), (vii) trigger ferroptosis with OxS and lipid peroxidation, and (viii) induce mitochondrial degeneration 27,146

Methodology was followed as outlined in the manufactures protocol for the Human GPX3 ELISA Detection Kit (NOVUS Biologicals)

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In summary, accumulating evidence points to metabolism as a key determinant of meningococcal colonization and invasion, with important differences between hypervirulent and carrier strains ( Table 2 )