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In vitro assays using BaF-BO3 cells transfected with the hGH receptor confirmed that AOD9604 does not compete for the hGH receptor and does not induce cell proliferation unlike intact hGH establishing that it operates via a novel mechanism distinct from traditional hGH-stimulated pathways

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If you wake at 6 PM, dosing at 8 PM captures the same receptor responsiveness window as a day-shift worker dosing at 8 AM