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For best outcomes, most patients undergo 48 sessions, spaced weekly or bi-weekly

In addition, the brain is rich in oxidizable substrates such as catecholamines and polyunsaturated fatty acids within neuronal membranes, rendering it particularly susceptible to oxidative damage

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In this context, metformin, a well-established initial treatment (Maruthur et al., 2016), distinguishes itself for its hypoglycemic ability and its broader effects such as enhanced endothelial function, reducing oxidative stress and insulin resistance, improving lipid profiles and managing fat redistribution (Rojas and Gomes, 2013)

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