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The bioavailability difference between the two routes compounds the distinction: topical application creates a localized skin depot, while injection delivers the peptide systemically at concentrations impossible to achieve through the skin barrier

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doi: 10.1016/j.physbeh.2015.06.001, 53

Together these papers provide an important update to our understanding of how cells change their metabolism when dysfunctional growth causes reactive oxygen to threaten their survival, and how those changes might influence therapeutic interventions