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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]

Additionally, GLP-1 RAs may alleviate symptoms of related adverse reactions

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Liraglutide may reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults at lower doses and can improve cardiovascular health metrics and insulin resistance

Testai FD, Gorelick PB, Chuang P-Y, Dai X, Furie KL, Gottesman RF, et al